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Product Name: BYL-719
Chemical Name: (S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide
SMILES Code: O=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CC(C(C)(C)C(F)(F)F)=NC=C3)S2
CAS NO: 161230-88-2 Product: ML224
Synonym: BYL719; BYL 719; Alpelisib
Chemical Formula: C19H22F3N5O2SMolecular Weight: 441.47
Appearance: Solid powderMedchemexpress
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).p97 inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: BYL-719 is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, which potently inhibits Akt phosphorylation in cells transformed with PI3Kα (IC50=74±15 nM) and shows significant reduced inhibitory activity in PI3Kβ or PI3Kδ isoforms transformed cellsPubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22306069

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Author: DNA_ Alkylatingdna