IL-11 Receptor Proteins Formulation Rchers are trying to use them to make a skin substitute for the therapy of burn wounds. A preliminary study showed that the application of bioactive milk proteins, lactoferrin, and whey proteins on a synthetic polymer (polycaprolactone) scaffold enhanced the growth, spread, and infiltration of keratinocytes and fibroblasts. Hence, it could be efficiently used to heal wounds [187]. Milk proteins have also been used straight on the skin for therapeutic purposes. Topical application of bovine colostrum preparations resulted in substantial improvement in the therapy of difficult-to-heal wounds brought on by buttock erythematosus and by erosion erythema when administered as help for systemic antibiotic therapy [174]. An ointment consisting of Gundelia (Gundelia tournefortii L.) extract with milk cream (GT/MC 4:1) was located to help the healing of second-degree burn within a rat model. Thirty-six male Wistar rats with second-degree burns on the skin were divided into three groups: one particular treated with silver sulfadiazine drug, a further treated with G. tournefortii L. extract composite with milk cream, and one untreated group. From the three, the GT/MC ointment group demonstrated one of the most effective healing. Right after 21 days of remedy, theMolecules 2021, 26,14 ofwound area was reduced, plus the wound healing method was enhanced substantially. Hence, such an ointment could help within the healing of burn wounds [188]. Bovine lactoferrin might be deemed as a topical treatment choice for the treatment of psoriatic plaque. This can be confirmed by research carried out on a group of 22 individuals with moderate plaque psoriasis who used ointments containing 10 and 20 lactoferrin. The psoriatic lesions treated with lactoferrin demonstrated improvements in elevation, redness, and scaling; nevertheless, the 20 ointment didn’t seem to become extra powerful than the ten [114]. Podolian cow milk has also been made use of as a raw material for skincare products within the kind of liquid hand soap. The item was found to demonstrate fantastic cleansing and antibacterial properties. The most effective was the soap containing five of Podolian milk, which reduced bacterial hand contamination by 98 . The antibacterial activity on the item derived from the presence of some milk protein, at the same time as different enzymes, for instance lysozyme (0.25 mg/L), lactoferrin, and lactoperoxidase [175]. One more study compared the effects of creams with nanoliposomes encapsulated with skimmed donkey milk with placebo on untreated skin in fifteen healthier volunteers. Shortly just after application, the creams demonstrated satisfactory moisturizing properties, which were maintained all through the entire period. Transepidermal water loss slightly decreased only after 4 weeks, and the pH worth was related following every single from the treatment options. The creams may possibly contribute to additional antiaging effects [176]. The formulations containing the skimmed donkey milk are described in detail in the Serbian patent (P-2016/0289; No 57752) [189]. Scientific publications with regards to the external application of colostrum to the skin are sparse. Nevertheless, several patents relating to colostrum-based dermocosmetics are pending. In accordance with the patent US5750149A [177], formulations containing horse colostrum collectively with horse milk have Epigen Proteins manufacturer already been clinically tested. The research investigated preparations with distinctive ratios of colostrum to milk content, i.e., 30 horse colostrum, 20 horse colostrum and 10 horse milk, ten horse colostrum and 20 horse.
