Product Name :
Spexin、NPQ (human, mouse, bovine)
CAS NO. :
1370290-58-6
Formula :
C74H114N20O19S1
Molecular Weight::
1619.88
Target:
Neuropeptide Y Receptor
Serial Number:
Asn-Trp-Thr-Pro-Gln-Ala-Met-Leu-Tyr-Leu-Lys-Gly-Ala-Gln-NH2
Short serial number :
NWTPQAMLYLKGAQ-NH2
Purity:
95%
Description :
Spexin (SPX, also called NPQ) is a gastro-intestinal peptide hormone. In situ hybridization localized its mRNA to the stomach and esophagus. Synthetic spexin induced dose-dependent contraction of stomach muscle, suggesting that it is involved in digestion. The results obtained by Rucinski et al. indicate that spexin may inhibit adrenocortical cell proliferation.Spexin is an endogenous satiety-inducing peptide and a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 = 45.7 and 112.2 nM, respectively), displaying no significant activity at galanin receptor 1. Spexin inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. It exhibits anxiolytic effects in vivo.
References:
[1].Identification of novel peptide hormones in the human proteome by hidden Markov model screening. [2].Expression of the spexin gene in the rat adrenal gland and evidences suggesting that spexin inhibits adrenocortical cell proliferation. [3]. Spexin expression in normal rat tissues.
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