Human LAYN Protein 5151

Additional Information:
accession Q6UX15|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundLayilin (LAYN) is a critical gene that regulates T cell function. LAYN is correlated with prognosis and immune infiltrating levels of, including those of CD8 T cells, CD4 T cells, macrophages, neutrophils, and DCs in multiple cancers, especially in colon and gastric cancer patients. In addition, LAYN expression potentially contributes to regulation of tumor-associated macrophages (TAMs), DCs, T cell exhaustion and Tregs in colon and gastric cancer.|molecular weightThe protein has a predicted MW of 25.4 kDa. Due to glycosylation, the protein migrates to 35-42 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human LAYN Protein 5151proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceLayilin (LAYN) is a critical gene that regulates T cell function. LAYN is correlated with prognosis and immune infiltrating levels of, including those of CD8 T cells, CD4 T cells, macrophages, neutrophils, and DCs in multiple cancers, especially in colon and gastric cancer patients. In addition, LAYN expression potentially contributes to regulation of tumor-associated macrophages (TAMs), DCs, T cell exhaustion and Tregs in colon and gastric cancer.Protein namesLayilinGene namesLAYN,LAYN UNQ208/PRO234Mass9606DaFunctionReceptor for hyaluronate.Subellular locationMembrane ; Single-pass type I membrane protein. Note=Colocalizes with TLN1 at the membrane ruffles.StructureInteracts with NF2, RDX and TLN1.DomainThTarget Relevance information above includes information from UniProt accession: Q6UX15The UniProt Consortium|