Mouse DDC Protein 2261

Additional Information:
accession O88533|express systemBaculovirus-Insect Cells|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundAromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in early infancy, and causes severe developmental disability and lifelong motor, behavioral, and autonomic symptoms including oculogyric crises (OGC), sleep disorder, and mood disturbance.|molecular weightThe protein has a predicted MW of 55.40 kDa same as Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse DDC Protein 2261proteinSize and concentration100, 500g and liquidFormLiquidStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped with dry ice.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceAromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in early infancy, and causes severe developmental disability and lifelong motor, behavioral, and autonomic symptoms including oculogyric crises (OGC), sleep disorder, and mood disturbance.Protein namesAromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC)Gene namesDdc,DdcProtein familyGroup II decarboxylase familyMass10090DaFunctionCatalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.Catalytic activityBINDING 82; /ligand=”substrate”; /evidence=”ECO:0000250|UniProtKB:P80041″; BINDING 148; /ligand=”pyridoxal 5′-phosphate”; /ligand_id=”ChEBI:CHEBI:597326″; /evidence=”ECO:0000250|UniProtKB:P20711″; BINDING 149; /ligand=”pyridoxal 5′-phosphate”; /ligand_id=”ChEBI:CHEBI:597326″; /evidence=”ECO:0000250|UniProtKB:P20711″; BINDING 192; /ligand=”substrate”; /evidence=”ECO:0000250|UniProtKB:P80041″; BINDING 246; /ligand=”pyridoxal 5′-phosphate”; /ligand_id=”ChEBI:CHEBI:597326″; /evidence=”ECO:0000250|UniProtKB:P20711″; BINDING 300; /ligand=”pyridoxal 5′-phosphate”; /ligand_id=”ChEBI:CHEBI:597326″; /evidence=”ECO:0000250|UniProtKB:P20711″PathwayPATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.StructureHomodimer.Target Relevance information above includes information from UniProt accession: O88533The UniProt Consortium|