Mouse RGM-C Protein 3791

Additional Information:
inaccessionQ7TQ32|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundRGM gene family (‘Repulsive Axonal Guidance molecules’ A, B and C), both RGM A and B are mostly expressed in central nervous system, while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A and B appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGM A appears in the neuroepithelium, and only RGM B in the peripheral nervous system.|molecular weightThe protein has a predicted MW of 40 kDa (mature)&26 kDa (C-terminus peptide)&14 kDa (N-terminus peptide). Due to enzyme lysis and glycosylation, the protein migrates to 55-60 kDa&36-40 kDa&20-25 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse RGM-C Protein 3791proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceRGM gene family (‘Repulsive Axonal Guidance molecules’ A, B and C),both RGM A and B are mostly expressed in central nervous system, while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A and B appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGM A appears in the neuroepithelium, and only RGM B in the peripheral nervous system.Protein namesHemojuvelin (Hemochromatosis type 2 protein homolog) (Hemojuvelin BMP coreceptor) (RGM domain family member C)Gene namesHjv,Hjv Hfe2 RgmcProtein familyRepulsive guidance molecule (RGM) familyMass10090DaFunctionActs as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.Subellular locationCell membrane ; Lipid-anchor, GPI-anchor. Note=Also released in the extracellular space.TissuesMuscle cell lineage.StructureInteracts with BMP2 and BMP4 (PubMed:16604073). Interacts with BMP6 (PubMed:19252486). Interacts with BMPR1B (By similarity). Interacts with TMPRSS6 (By similarity).Post-translational modificationAutocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space; regulates HJV activity in BMP signaling and thefore iron homeostasis.Target Relevance information above includes information from UniProt accession: Q7TQ32The UniProt Consortium|