Name :
CD244 (Human) Recombinant Protein
Biological Activity :
Human CD244 (Q9BZW8-2, Cys22-Arg221) partial recombinant protein with hFc tag at C-Terminus expressed in HEK293 cells.Recombinant Human Protein,Recombinant Human Proteins,Human Recombinant Protein,Human Recombinant Proteins,HuPro
Tag :
Result of bioactivity analysis
Protein Accession No. :
Q9BZW8-2
Protein Accession No.URL :
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=51744
Amino Acid Sequence :
Cys22-Arg221
Molecular Weight :
49
Storage and Stability :
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.Aliquot to avoid repeated freezing and thawing.
Host :
Human
Interspecies Antigen Sequence :
Preparation Method :
Mammalian cell (HEK293) expression system
Purification :
Quality Control Testing :
SEC-HPLC and Tris-Bis PAGE SEC-HPLC The purity of Human 2B4/CD244/SLAMF4 is greater than 95% as determined by SEC-HPLC. Tris-Bis PAGE Human 2B4/CD244/SLAMF4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Storage Buffer :
Lyophilized from sterile distilled Water is > 100 ug/mL
Applications :
Enzyme-linked Immunoabsorbent Assay， Immobilized Human CD48, His Tag at 1 ug/mL (100 uL/well) on the plate. Dose response curve for Human 2B4, hFc Tag with the EC50 of 0.45 ug/mL determined by ELISA. Functional Study， SDS-PAGE，
Gene Name :
CD244
Gene Alias :
2B4, NAIL, NKR2B4, Nmrk, SLAMF4
Gene Description :
CD244 molecule, natural killer cell receptor 2B4
Gene Summary :
Natural killer (NK) cells express both activating and inhibitory cell surface receptors. Inhibitory signaling receptors all possess cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, or ITIMs, whereas the activating receptors lack ITIMs and associate with DAP12 (TYROBP; MIM 604142), which contains an immunoreceptor tyrosine-based activation motif, or ITAM. Killer cell immunoglobulin (Ig)-like receptors, or KIRs (see KIR2DL1; MIM 604936), and other NK cell receptors interact with major histocompatibility complex (MHC) molecules (see MIM 142800). Members of the CD2 (MIM 186990) family adhere to each other instead. The cell surface glycoprotein 2B4 is related to CD2 and is implicated in the regulation of NK- and T-cell function (Boles et al., 1999 [PubMed 10458320]).[supplied by OMIM
Other Designations :
CD244 natural killer cell receptor 2B4|NK cell activation inducing ligand NAIL|OTTHUMP00000027884|natural killer cell receptor 2B4
MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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