The development of advanced wound dressings that closely mimic the natural extracellular matrix (ECM) is a critical challenge in regenerative medicine. In this study, we designed and synthesized a novel…
**Background** Lysine methyltransferases play a critical role in epigenetic regulation by modifying histone proteins, which in turn modulates gene expression and cellular function. Among these, SETD8 (also known as KMT5A)…
DNA methylation is a key epigenetic modification regulated by DNA methyltransferases (DNMTs), which transfer a methyl group from S-adenosyl-L-methionine (SAM) to cytosine residues in CpG dinucleotides. Aberrant DNA methylation is…
**Background** Protein kinase C (PKC) is a family of serine/threonine kinases that play critical roles in regulating various cellular processes, including signal transduction, cell growth, and inflammation. Among its isoforms,…
The extracellular matrix (ECM) plays a central role not only as a structural scaffold but also as an active regulator of cellular and tissue functions during development, homeostasis, and disease.…
**Background** Pyruvate dehydrogenase kinase (PDK) plays a critical role in regulating the pyruvate dehydrogenase complex, which serves as the gatekeeper for glucose oxidation in the mitochondria. In many types of…
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation, joint destruction, and systemic autoantibody production. A critical feature of RA pathogenesis is the formation of ectopic lymphoid…
Salmonella virulence is largely mediated by two type III secretion systems (T3SS) that deliver effector proteins from the bacterium to a host cell; however, the secretion signal is poorly defined.…
Cell migration is a fundamental process in development, wound healing, and cancer metastasis. While traditional studies have relied on two-dimensional (2D) substrates to analyze cell movement, it has become increasingly…
Within cells, lipids are stored in the form of lipid droplets (LDs), consisting of a neutral lipid core surrounded by a phospholipid monolayer and an outer layer of proteins. LDs…