The ideal characterized PAS-LuxR family members member is PimM, which in Streptomyces natalensis binds to 8 promoters and activates expression of the biosynthetic genes for manufacturing of the polyene antifungal antibiotic pimaricin (also known as natamycin)
The 1st gene in this twogene operon, scab79591 (herein referred to as cfaR), encodes...