Ion but not in yet another. The rs10757278 polymorphism might be in close linkage with unique nearby causal variants in different populations. Nonetheless, owing for the restricted quantity of relevant research among African Americans integrated within this meta-analysis, the observed ethnic distinction in this Epigenetics meta-analysis can also be most likely to become caused by likelihood for the reason that research with modest sample sizes might have insufficient statistical power to detect a slight effect or could have generated a fluctuated danger estimate. Reference Caucasian Caucasian Caucasian Caucasian Caucasian, African American Caucasian Caucasian Caucasian Caucasian Caucasian, African American East Asian Caucasian East Asian Caucasian Caucasian East Asian Caucasian Caucasian Caucasian East Asian Caucasian, African American rs2383207 rs10757278 rs4977574 rs2383207 rs2383207 CT or MRI confirmed CT or MRI confirmed CT or MRI confirmed IS per WHO criteria IS per WHO criteria rs1333049 IS per WHO criteria rs10757278 CT or MRI confirmed rs10757278 CT or MRI confirmed rs2383206 CT or MRI confirmed Ethnicity Age, sex, ethnicity Age, sex, ethnicity Ethnicity Age, sex, ethnicity Ethnicity Age, sex, ethnicity Age, sex, resident area Ethnicity rs10757278 IS patients rs10757278 IS per ICD-9 criteria Ethnicity, resident area Ethnicity, time of follow-up rs10757274 IS per ICD-9 criteria Ethnicity rs10757274 CT or MRI confirmed Ethnicity rs1537378 CT or MRI confirmed Age, ethnicity rs1333049 IS per ICD-9 criteria Age, sex, ethnicity, web-site of enrolment 209/2064 1164/18438 503/784 524/12856 999/1055 163/5099 352/423 229/229 834/665 642/1361 1780/12253 12389/65004 6865/11395 1195/1664 879/824 rs10757278 IS per WHO criteria Sex, ethnicity 636/809 rs10757278 CT or MRI confirmed Age, sex, ethnicity, site of enrolment 932/4150 rs2383207 IS per WHO criteria Age, sex, ethnicity, time of baseline investigation 2725/1840 rs10757278 CT or MRI confirmed Ethnicity 705/14993 Population Population Population Population Population Population Population Population Population Hospital Hospital Population Population Population Population Population Population Population Population rs2383207 IS per WHO criteria Age, sex, ethnicity 249/268 Population rs10757274 CT or MRI confirmed Age, ethnicity, smoking status 254/254 Population NA Year Ethnicity Ethnic groups Polymorphism Case Match criteria for control No. of cases/ controls Source of manage Genotyping approach Zee 2007 American Matarin 2008 American Chip Chip MassArray TaqMan Taqman MassArray Chip inhibitor Kinetic PCR Taqman TaqMan MassArray SNPstream Taqman Golden Gate Taqman Chip Chip, Taqman KASPar, Taqman LDR MassArray Helgadottir 2008 European Smith 2009 Swedish Gschwendtner 2009 European, African American Lemmens 2009 Belgian Karvanen 2009 European Ikram 2009 European Luke 2009 Austrian Yamagishi 2009 American Ding 2009 Chinese Wahlstrand 2009 Swedish 4 Hu 2009 Chinese Plant 2011 American Olsson 2011 Swedish Lin 2011 Chinese Bellenguez 2012 European, American Traylor 2012 European Cheng 2012 European, American Zhang 2012 Chinese Heckman 2013 American doi:ten.1371/journal.pone.0090255.t001 Ischemic Stroke Genetics Ischemic Stroke Genetics Thus, additional research such as a wider spectrum of subjects to investigate the role of chromosome 9p21 variants within this population will probably be needed. Meta-analysis is typically dominated by some big studies, which markedly reduces the evidence from smaller sized studies. Having said that, inside the stratified analysis according to sample size, considerably incre.Ion but not in a different. The rs10757278 polymorphism may well be in close linkage with distinctive nearby causal variants in various populations. Nonetheless, owing for the restricted quantity of relevant studies among African Americans incorporated within this meta-analysis, the observed ethnic difference within this meta-analysis can also be likely to become brought on by likelihood mainly because research with smaller sample sizes might have insufficient statistical power to detect a slight effect or may have generated a fluctuated risk estimate. Reference Caucasian Caucasian Caucasian Caucasian Caucasian, African American Caucasian Caucasian Caucasian Caucasian Caucasian, African American East Asian Caucasian East Asian Caucasian Caucasian East Asian Caucasian Caucasian Caucasian East Asian Caucasian, African American rs2383207 rs10757278 rs4977574 rs2383207 rs2383207 CT or MRI confirmed CT or MRI confirmed CT or MRI confirmed IS per WHO criteria IS per WHO criteria rs1333049 IS per WHO criteria rs10757278 CT or MRI confirmed rs10757278 CT or MRI confirmed rs2383206 CT or MRI confirmed Ethnicity Age, sex, ethnicity Age, sex, ethnicity Ethnicity Age, sex, ethnicity Ethnicity Age, sex, ethnicity Age, sex, resident area Ethnicity rs10757278 IS individuals rs10757278 IS per ICD-9 criteria Ethnicity, resident location Ethnicity, time of follow-up rs10757274 IS per ICD-9 criteria Ethnicity rs10757274 CT or MRI confirmed Ethnicity rs1537378 CT or MRI confirmed Age, ethnicity rs1333049 IS per ICD-9 criteria Age, sex, ethnicity, web-site of enrolment 209/2064 1164/18438 503/784 524/12856 999/1055 163/5099 352/423 229/229 834/665 642/1361 1780/12253 12389/65004 6865/11395 1195/1664 879/824 rs10757278 IS per WHO criteria Sex, ethnicity 636/809 rs10757278 CT or MRI confirmed Age, sex, ethnicity, internet site of enrolment 932/4150 rs2383207 IS per WHO criteria Age, sex, ethnicity, time of baseline investigation 2725/1840 rs10757278 CT or MRI confirmed Ethnicity 705/14993 Population Population Population Population Population Population Population Population Population Hospital Hospital Population Population Population Population Population Population Population Population rs2383207 IS per WHO criteria Age, sex, ethnicity 249/268 Population rs10757274 CT or MRI confirmed Age, ethnicity, smoking status 254/254 Population NA Year Ethnicity Ethnic groups Polymorphism Case Match criteria for control No. of cases/ controls Source of control Genotyping process Zee 2007 American Matarin 2008 American Chip Chip MassArray TaqMan Taqman MassArray Chip Kinetic PCR Taqman TaqMan MassArray SNPstream Taqman Golden Gate Taqman Chip Chip, Taqman KASPar, Taqman LDR MassArray Helgadottir 2008 European Smith 2009 Swedish Gschwendtner 2009 European, African American Lemmens 2009 Belgian Karvanen 2009 European Ikram 2009 European Luke 2009 Austrian Yamagishi 2009 American Ding 2009 Chinese Wahlstrand 2009 Swedish four Hu 2009 Chinese Plant 2011 American Olsson 2011 Swedish Lin 2011 Chinese Bellenguez 2012 European, American Traylor 2012 European Cheng 2012 European, American Zhang 2012 Chinese Heckman 2013 American doi:ten.1371/journal.pone.0090255.t001 Ischemic Stroke Genetics Ischemic Stroke Genetics Thus, additional research like a wider spectrum of subjects to investigate the part of chromosome 9p21 variants within this population might be needed. Meta-analysis is frequently dominated by some significant studies, which markedly reduces the proof from smaller research. Nevertheless, within the stratified analysis in accordance with sample size, substantially incre.
