In this regard, Fitzcharles and colleagues [7,8] published a set of recommendations in order to discuss the legitimacy of FMS and to guide its diagnosis and management. Thus, involving ABT-737 solubility primary care physicians in the PASSAGE Program could be very beneficial for FMS patients in order to provide this often neglected clientele of patients with effective self-management of their symptoms. In conclusion, our new MK-5172MedChemExpress MK-5172 multicomponent interdisciplinary self-management intervention for FMS was found to be effective in improving the patients’ global impression of change in terms of pain, functioning and QOL as well as in increasing their perceived pain relief. We suggest including this type of measures in future clinical trials on FMS as they appear to capture an important aspect of the patient experience. Further research on the long-term efficacy of the PASSAGE Program is nonetheless needed as well as studies involving primary care physicians in the intervention.Supporting InformationS1 CONSORT Checklist. CONSORT Checklist. (PDF)PLOS ONE | DOI:10.1371/journal.pone.0126324 May 15,22 /Multicomponent Group Intervention for Self-Management of FibromyalgiaS1 Dataset. Original data. (SAS7BDAT) S1 Protocol. Trial protocol (French). (PDF) S2 Protocol. Trial protocol methodology (English). (PDF)AcknowledgmentsWe are grateful to all the patients who took part in the study, and to the members of the study team, Edith B ub?Quesnel, Jos Boucher, ic Chaize, Christian Cloutier, Roxanne Daoust, Sophie Duhaime, Annie Lachapelle, ilie Lagueux, Serge Lalonde, Sylvie Lamoureux, Marjolaine Landry, Niet Nguyen, Kathy Perrier, Vanessa Roy, Mario Siane from the Universit?de Sherbrooke and the Universit?du Qu ec en Abitibi-T iscamingue. We also wish to thank Mr Louis Coupal (Impacts Inc.) for his helpful comments and suggestions for the statistical analyses. Finally, thanks are due to Genevi e Lavigne PhD who helped in the preparation and edition of the present manuscript.Author ContributionsConceived and designed the experiments: PB AL SM RCH JC IG JBS MC. Analyzed the data: AL PB RCH MC. Wrote the paper: PB AL SM RCH JC IG JBS MC.Reference1. 2. 3. Gran JT. The epidemiology of chronic generalized musculoskeletal pain. Best Practice ResearchClinical Rheumatology. 2003; 17: 547?61. Abeles AM, Pillinger MH, Solitar BM, Abeles M. Narrative review: the pathophysiology of fibromyalgia. Annals of Internal Medicine. 2007; 146: 726?34. PMID: 17502633 Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis care research. 2010; 62: 600?10. Branco JC, Bannwarth B, Failde I, Abello Carbonell J, Blotman F, Spaeth M, et al. Prevalence of fibromyalgia: a survey in five European countries. Seminars in arthritis and rheumatism. 2010; 39: 448?453. doi: 10.1016/j.semarthrit.2008.12.003 PMID: 19250656 McGillion MH, Watt-Watson J, Stevens B, Lefort SM, Coyte P, Graham A. Randomized controlled trial of a psychoeducation program for the self-management of chronic cardiac pain. Journal of pain and symptom management. 2008; 36: 126?40. doi: 10.1016/j.jpainsymman.2007.09.015 PMID: 18395397 White KP, Speechley M, Harth M, Ostbye T. The London Fibromyalgia Epidemiology Study: the prevalence of fibromyalgia syndrome in London, Ontario. The Journal of rheumatology. 1999; 26: 1570?1576. PMID: 10405947 Fitzcharles M-A, Ste-Marie PA, Goldenberg DL, P.In this regard, Fitzcharles and colleagues [7,8] published a set of recommendations in order to discuss the legitimacy of FMS and to guide its diagnosis and management. Thus, involving primary care physicians in the PASSAGE Program could be very beneficial for FMS patients in order to provide this often neglected clientele of patients with effective self-management of their symptoms. In conclusion, our new multicomponent interdisciplinary self-management intervention for FMS was found to be effective in improving the patients’ global impression of change in terms of pain, functioning and QOL as well as in increasing their perceived pain relief. We suggest including this type of measures in future clinical trials on FMS as they appear to capture an important aspect of the patient experience. Further research on the long-term efficacy of the PASSAGE Program is nonetheless needed as well as studies involving primary care physicians in the intervention.Supporting InformationS1 CONSORT Checklist. CONSORT Checklist. (PDF)PLOS ONE | DOI:10.1371/journal.pone.0126324 May 15,22 /Multicomponent Group Intervention for Self-Management of FibromyalgiaS1 Dataset. Original data. (SAS7BDAT) S1 Protocol. Trial protocol (French). (PDF) S2 Protocol. Trial protocol methodology (English). (PDF)AcknowledgmentsWe are grateful to all the patients who took part in the study, and to the members of the study team, Edith B ub?Quesnel, Jos Boucher, ic Chaize, Christian Cloutier, Roxanne Daoust, Sophie Duhaime, Annie Lachapelle, ilie Lagueux, Serge Lalonde, Sylvie Lamoureux, Marjolaine Landry, Niet Nguyen, Kathy Perrier, Vanessa Roy, Mario Siane from the Universit?de Sherbrooke and the Universit?du Qu ec en Abitibi-T iscamingue. We also wish to thank Mr Louis Coupal (Impacts Inc.) for his helpful comments and suggestions for the statistical analyses. Finally, thanks are due to Genevi e Lavigne PhD who helped in the preparation and edition of the present manuscript.Author ContributionsConceived and designed the experiments: PB AL SM RCH JC IG JBS MC. Analyzed the data: AL PB RCH MC. Wrote the paper: PB AL SM RCH JC IG JBS MC.Reference1. 2. 3. Gran JT. The epidemiology of chronic generalized musculoskeletal pain. Best Practice ResearchClinical Rheumatology. 2003; 17: 547?61. Abeles AM, Pillinger MH, Solitar BM, Abeles M. Narrative review: the pathophysiology of fibromyalgia. Annals of Internal Medicine. 2007; 146: 726?34. PMID: 17502633 Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis care research. 2010; 62: 600?10. Branco JC, Bannwarth B, Failde I, Abello Carbonell J, Blotman F, Spaeth M, et al. Prevalence of fibromyalgia: a survey in five European countries. Seminars in arthritis and rheumatism. 2010; 39: 448?453. doi: 10.1016/j.semarthrit.2008.12.003 PMID: 19250656 McGillion MH, Watt-Watson J, Stevens B, Lefort SM, Coyte P, Graham A. Randomized controlled trial of a psychoeducation program for the self-management of chronic cardiac pain. Journal of pain and symptom management. 2008; 36: 126?40. doi: 10.1016/j.jpainsymman.2007.09.015 PMID: 18395397 White KP, Speechley M, Harth M, Ostbye T. The London Fibromyalgia Epidemiology Study: the prevalence of fibromyalgia syndrome in London, Ontario. The Journal of rheumatology. 1999; 26: 1570?1576. PMID: 10405947 Fitzcharles M-A, Ste-Marie PA, Goldenberg DL, P.
