Tic insufficiency is significantly less frequent in variety DM,than in earlier study,almost certainly since pancreatic diabetes situations were excluded. Exocrine pancreatic insufficiency was not related together with the duration of DM,BMI,HbAc level,pancreatic steatosis or the presence of microvascular complications of DM. Disclosure of Interest: None declaredP BETAINE ATTENUATES ALCOHOLIC PANCREATIC STEATOSIS Through DOWNREGULATION PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26663416 OF STEROL REGULATORY ELEMENT BINDING PROTEINC W.J. Yang,J. Li,J.H. Gao,Z.Y. Huang,C.W. Tang Division of Gastroenterology,West China Hospital,Sichuan University,Chengdu,China Get in touch with E-mail Address: yangwenjuan Introduction: Increasing research have shown that Tubacin chronic alcohol consumption brought on pancreatic steatosis. Nonetheless,health-related interventions for alcoholic pancreatic steatosis haven’t been extensively investigated. Betaine was found to alleviate alcoholic fatty liver illness in multiple studies. In the present study,we investigated the effect of betaine on alcoholic pancreatic steatosis and its mechanism. Aims Procedures: male Wistar rats have been randomized into control,alcohol and alcohol betaine group with animals in each group. Rats in the 3 groups had been provided totally free access to distilled water,ethanol ( ,vv) and ethanol ( ,vv) plus betaine ( ,wv),respectively,for six months. Morphological alterations of the pancreatic acinar cells had been identified by hematoxylineosin staining,oil red O staining and transmission electron microscope. Pancreatic triglyceride (TG) and total cholesterol (TC) contents had been measured by enzymatic colorimetric assay. Serum adiponectin levels had been determined by enzymelinked immunosorbent assay. The protein and mRNA expression of pancreatic adiponectin receptor (AdipoR),AdipoR,sterol regulatory element binding proteinsc (SREBPc),and SREBP have been determined by immunohistochemistry (IHC),Western blot (WB) and quantitative realtime PCR (qRTPCR). The impact of betaine ( mmolL) andor adiponectin mgmL) on SREBPP ADIPOSE TISSUE IS TOXIC FOR PANCREATIC PARENCHYMA: COCULTURE MODEL OF PANCREATIC TISSUE AND VISCERAL ADIPOSE TISSUE FROM OBESE Sufferers B. Jais,,J. Cros,P. Bourgoin,S. Laouirem,M. le Gall,K. Arapis,J.P. Marmuse,A. Sauvanet,P. Ruszniewski,V. Paradis,P. Bedossa,A. Couvelard,V. Rebours Centre de recherche sur l’inflammation,INSERMUMR ,Paris,Service de Pancre tologie Gastroente ologie,Ho^pital Beaujon,Clichy,Service de Chirugie Digestive,Service de Chirurgie Digestive,Hopital Bichat,Paris,Service de chirurgie digestive,Ho^pital Beaujon,Clichy,France Speak to E mail Address: vinciane.reboursbjn.aphp.fr Introduction: Lately,obesity and metabolic syndrome happen to be identified as independent danger elements for chronic pancreatitis and pancreatic cancer. Visceral adipose tissue (VAT) of obese sufferers induces proinflammatory cytokines synthesis (TNF,IL ,adiponectin,leptin) recognized to become involved in pancreatic fibrogenesis by the activation of pancreatic stellate cells (PSC).A c expression in ethanoltreated ( mmolL) SW pancreatic adenocarcinoma cells was also assessed by WB and qRTPCR. Benefits: Alcoholinduced morphological alterations with the pancreatic acinar cells,including lipid droplets,swelling mitochondria and lowered zymogen granules,had been attenuated after betaine remedy. Compared with handle group,pancreatic TG level in ethanol group was markedly increased by . (P.). Interestingly,betaine remedy considerably reduced pancreatic TG level of alcoholic rats by . (P.). Having said that,pancreatic TC content material was equivalent among the 3 group.