Ver, as often hydrogen peroxide molecules (cf. Scheme to yield directly H2 O2 . –generates claimed, the so named Weissberger system– 1) , or on account of the decomposition –generates hydrogen peroxide Fenton sort ascorbate–Cu(II/Cu(I)–dioxygen of H2O2 by Cu(I) complicated via molecules (cf. reaction, the Weissberger on account of the decomposition of most potent generators of hydroxyl Scheme 1) , or method became certainly one of the H2 O2 by Cu(I) complicated by way of Fenton sort reaction, radicals . the Weissberger method became among essentially the most potent generators of hydroxylradicals .Scheme 1. Generation of H2O2 – two the Weissberger method composed of ascorbate and Cu(II) beneath by way of 2 aerobic situations. – represents ascorbate anion and and DHA represents dehydroascorbate. aerobic circumstances. AscHAscH represents ascorbate anion DHA represents dehydroascorbate.Scheme 1. Generation of H O by way of the Weissberger technique composed of ascorbate and Cu(II) underWhen the Weissberger systemIn any case, it must be pointed out that speak about ascorbate autoxidation . has no further oxidizable substrate, we the biological ascorbate autoxidation . In any case, it really should be pointed out that metal cations of iron, consequences of interactions of vitamin C with biogenic transition the biological consequences of interactions of vitamin C withfully understood but. More than the previous decade, the copper, or manganese have not been biogenic transition metal cations of iron, copper, or manganese have not been completely understood yet. Over addition to its superior explored pro-oxidant Diversity Library Advantages properties of ascorbate have been investigated inside the past decade, the prooxidant properties of ascorbate happen to be investigated as well as its greater explored antioxidant function. antioxidant function. oxidizable Bafilomycin C1 Autophagy substrates are simultaneously present, the reaction merchandise conWhen sist of each oxidized/decomposed substrate  and DHA–dehydroascorbate, whose When oxidizable substrates are simultaneously present, the reaction products consist molecules in aqueous milieus hydrolyze speedy to 2,3-diketo-L-gulonic acid . Although for of both oxidized/decomposed substrate  and DHA–dehydroascorbate, whose molethe next sections of hydrolyze rapidly the complexation of ascorbate with one more for the cules in aqueous milieus this minireviewto 2,3-diketo-L-gulonic acid . Although biogenic transition this minireview the the reader could discover some complexation kinetics trannext sections of metal is just not crucial,complexation of ascorbate with a further biogenicand/or sition equilibrium data involving ascorbate and quite a few metal cations, e.g., within the paper by Fornaro metal just isn’t important, the reader could obtain some complexation kinetics and/or equiand Coichev . Among the regularly cited statements in literature is the fact that copper cations librium information amongst ascorbate and numerous metal cations, e.g., within the paper by Fornaro released from the ceruloplasmin macromolecule are extensively entrapped by albumin and Coichev . Among the often cited statements in literature is the fact that copper cations present inside the bloodstream. This tenet is naturally in aspect correct, but it ought to also be admitted released from the ceruloplasmin macromolecule are extensively entrapped by albumin that the anions of ascorbate are the most likely co-responsible for the release of copper present in thefrom ceruloplasmin. The charge harge interaction amongst AscH- and, e.g., cations bloodstream. This tenet.