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Biological course of action, molecular function, and molecular pathway, was used to categorize
Biological course of action, molecular function, and molecular pathway, was applied to categorize the proteins into households and subfamilies with shared functions. Statistical analysis. All of the outcomes are presented as the indicates 6 SD. The statistical significance was determined by 1-way analysis of variance followed by post hoc test (Dr. SPSS II, Chicago, IL). Variations have been thought of substantial when p , 0.05. 1. Maitra, A. et al. Genomic alterations in cultured human embryonic stem cells. Nat. Genet. 37, 1099103 (2005). 2. Baker, D. E. et al. Adaptation to culture of human embryonic stem cells and oncogenesis in vivo. Nat. Biotechnol. 25, 20715 (2007). three. Sareen, D. et al. Chromosome 7 and 19 trisomy in cultured human neural progenitor cells. PLoS One four, e7630 (2009). 4. Ivanovic, Z. Hypoxia or in situ normoxia: The stem cell paradigm. J. Cell. Physiol. 219, 27175 (2009). five. Ames, B. N., Shigenaga, M. K. Hagen, T. M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. U. S. A. 90, 7915922 (1993). six. van Gent, D. C., Hoeijmakers, J. H. Kanaar, R. Chromosomal stability along with the DNA double-stranded break connection. Nat. Rev. Genet. two, 19606 (2001). 7. Wang, F., Thirumangalathu, S. Loeken, M. R. Establishment of new mouse embryonic stem cell lines is improved by physiological glucose and oxygen. Cloning Stem Cells 8, 10816 (2006). 8. Fehrer, C. et al. Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan. Aging Cell 6, 74557 (2007). 9. Li, T. S. Marban, E. Physiological levels of reactive oxygen species are expected to keep genomic stability in stem cells. Stem Cells 28, 1178185 (2010). ten. Li, T. S. et al. Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair. Cardiovasc. Res. 89, 15765 (2011). 11. Noon, A. T. Goodarzi, A. A. 53BP1-mediated DNA double strand break repair: insert negative pun right here. DNA Repair (Amst) ten, 1071076 (2011). 12. Kitagawa, R. Kastan, M. B. The ATM-dependent DNA damage signaling pathway. Cold Spring Harb. Symp. Quant. Biol. 70, 9909 (2005). 13. Kinoshita, T. et al. Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells. Biochem. Biophys. Res. Commun. 407, 32126 (2011). 14. Foreman, J. et al. Reactive oxygen species produced by NADPH oxidase regulate plant cell development. Nature 422, 44226 (2003). 15. Niethammer, P., Grabher, C., Look, A. T. Mitchison, T. J. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature 459, 99699 (2009). 16. Owusu-Ansah, E. AMPK supplier Banerjee, U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature 461, 53741 (2009). 17. Costa, J. L., Meijer, G., Ylstra, B. Caldas, C. Array comparative genomic hybridization copy quantity profiling: a new tool for translational research in solid malignancies. Semin. Radiat. Oncol. 18, 9804 (2008). 18. Robinton, D. A. Daley, G. Q. The promise of HSV-2 Compound induced pluripotent stem cells in research and therapy. Nature 481, 29505 (2012). 19. White, M. P., Rufaihah, A. J., Liu, L., Ghebremariam, Y. T., Ivey, K. N., Cooke, J. P. Srivastava, D. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem Cells 31, 9203 (2013). 20. Takahashi, K. et al. Induction of pluripote.

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Author: DNA_ Alkylatingdna