Product Name :
Z-HFF-OEt
CAS NO. :
13053-61-7
Formula :
C34H37O6N5
Molecular Weight::
611.69
Target:
CXCR
Serial Number:
Cbz-His-Phe-Phe-OEt
Short serial number :
Z-HFF-OEt
Purity:
95%
Description :
zHFFe, a good substrate for pepsin. Hertel et al identified zHFFe as a potent inhibitor of zero-trans glucose flux with a Ki of 26 μM. Similar to HIV protease inhibitors, transport inhibition by this peptide was acute, non-competitive, and reversible. Within a Xenopus oocyte expression system, zHFFe acutely and reversibly inhibited GLUT4-mediated glucose uptake, whereas GLUT1 activity was unaffected at concentrations as high as 1 mM.
References:
[1].A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity. [2]. Endoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocation.
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