Product Name :
Pep2m, myristoylated
CAS NO. :
1423381-07-0
Formula :
C63H118O14N18S1
Molecular Weight::
1383.79
Target:
PKC
Serial Number:
Myristicacid-Lys-Arg-Met-Lys-Val-Ala-Lys-Asn-Ala-Gln
Short serial number :
Myristicacid-KRMKVAKNAQ
Purity:
95%
Description :
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC).Pep2m, myristoylated acetate, a cell-permeable myristoylated form of pep2m, is a peptide inhibitor of the GluA2 subunit binding to NSF, reducing postsynaptic currents in CA1 neurons, AMPA-mediated hippocampal neuron currents, and AMPA receptor surface expression.
References:
[1].Yudong Yao, et al. PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors. J Neurosci. 2008 Jul 30; 28(31): 7820-7827. [2].Nicole C George, et al. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019; 15: 1744806919840582.
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