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Product Name :
Papain Inhibitor

CAS NO. :
70195-20-9

Formula :
C19H29N7O6

Molecular Weight::
451.48

Target:

Serial Number:
Gly-Gly-Tyr-Arg

Short serial number :
GGYR

Purity:
95%

Description :
Papain Inhibitor is a papain inhibitor, a cysteine protease found in papaya and mountain papaya. The mechanism of action is the cleavage of deprotonated Cys-25 peptide bonds by His-159. Asparagine-175 contributes to the imidazole ring orientation of His-159 and deprotonation occurs. Cys-25 attacks the carbonyl carbon of the peptide backbone, freeing the amino terminus of the peptide to form a covalent acylase intermediate. This enzyme deacylates through the water molecule and releases the carboxy-terminal portion of the peptide. It is well known that in immunology, papain cleaves the Fc moiety of Fab (antigen-binding) and immunoglobulins (antibodies). Papain tends to cleave between (hydrophobic)- (Arg or Lys) (not Val). Hydrophobic is Ala, Val, Leu, Ile, Phe, Trp, or Tyr. Papain isolates cells in the first step of cell culture. It can also be used as a component in various enzymatic debriding media, especially Accuzyme. These are some chronic wound care to remove necrotic tissue. Papain can also be used as an ingredient in some toothpastes or teeth whitening.

References:

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: DNA_ Alkylatingdna