Product Name :
OM99-2
CAS NO. :
314266-76-7
Formula :
C41H64N8O14
Molecular Weight::
892.99
Target:
Beta-secretase
Serial Number:
Glu-Val-Asn-Leu-psi[CHOH-CH2]-Ala-Ala-Glu-Phe
Short serial number :
EVNL-psi[CHOH-CH2]-AAEF
Purity:
95%
Description :
OM99-2, an eight residue peptidomimetic, is a potent and tight-binding inhibitor of human brain memapsin 2 (β-secretase) with a Ki of 9.58 nM. It significantly promotes the development of BACE1 inhibitor and has the potential to study Alzheimer’s disease.
References:
[1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. [2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. [3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. [4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422.
Related websites: https://www.medchemexpress.com/antibodies.html
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