Product Name :
Hexa-D-arginine (Furin Inhibitor II)
CAS NO. :
673202-67-0
Formula :
C36H75N25O6
Molecular Weight::
954.14
Target:
Bacterial
Serial Number:
DArg-DArg-DArg-DArg-DArg-DArg-NH2
Short serial number :
rrrrrr-NH2
Purity:
95%
Description :
Hexa-D-arginine amide is a potent furin inhibitor with a Ki of 0.106 μM. It also inhibited the related convertases PACE4 and prohormone convertase-1 (PC1) with Ki values of 0.58 μM and 13 μM, respectively. The stable hexapeptide exhibited protection against anthrax toxemia in vitro and in vivo.
References:
[1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9. [2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5. [3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9.
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