Product Name :
(Tyr0,Trp2)-Melanocyte-Stimulating Hormone-Release Inhibiting Factor;Tyr-W-MIF I
CAS NO. :
144450-13-5
Formula :
C27H32N6O5
Molecular Weight::
520.58
Target:
Opioid Receptor
Serial Number:
Tyr-Pro-Trp-Gly-NH2
Short serial number :
YPWG-NH2
Purity:
≥95%
Description :
Tyr-W-MIF-I, a member of the Tyr-MIF-I family, was isolated from the frontal cortex of human brain tissue as well as from bovine hypothalami. It can act as an opiate agonist as well as an antagonist. As an opiate agonist, it was more potent than the other structurally similar peptides, including Tyr-MIF-I.
References:
[1]. Yang YR, et L. Opioid and antiopioid actions of Tyr-MIF-1, Tyr-W-MIF-1 and hemorphin-4 on rat locus coeruleus neurons: intracellular recording in vitro. Chin J Physiol. 1997 Sep 30;40(3):131-5. [2]. Gergen KA, et al. Expression of the FOS proto-oncogene protein in brain after ICV administration of Tyr-W-MIF-1 (Tyr-Pro-Trp-Gly-NH2). Peptides. 1994;15(8):1505-11. [3]. Gergen KA, et al. Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors. Eur J Pharmacol. 1996 Mar 18;298(3):235-9. [4]. Harrison LM, et al. Tyr-W-MIF-1 attenuates down-regulation of opiate receptors in SH-SY5Y human neuroblastoma cells. J Pharmacol Exp Ther. 1998 Feb;284(2):611-7. [5]. Erchegyi J, et al. Isolation of a novel tetrapeptide with opiate and antiopiate activity from human brain cortex: Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1). Peptides. 1992 Jul-Aug;13(4):623-31.
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