Product Name :
KALA Amphipathic Peptide
CAS NO. :
187987-64-0
Formula :
C144H248N40O35S1
Molecular Weight::
3131.82
Target:
others
Serial Number:
Trp-Glu-Ala-Lys-Leu-Ala-Lys-Ala-Leu-Ala-Lys-Ala-Leu-Ala-Lys-His-Leu-Ala-Lys-Ala-Leu-Ala-Lys-Ala-Leu-Lys-Ala-Cys-Glu-Ala-OH
Short serial number :
WEAKLAKALAKALAKHLAKALAKALKACEA
Purity:
95%
Description :
KALA is an amphiphilic peptide that forms an α-helical structure at physiological pH. KALA modifies a plasmid DNA-encapsulating liposomal membrane and is used as a fusogenic peptide in order to achieve effective liver targeting and transfection of DNA via galactose receptors.KALA is a cationic amphipathic cell-penetrating peptide (CPP). At pH 7.5, it assumes an α-helix conformation. KALA binds oligonucleotides and disrupts cell membrane. Therefore, it can be used as a DNA transfection reagent.
References:
[1]. Naoya Miura, et al. Identification and Evaluation of the Minimum Unit of a KALA Peptide Required for Gene Delivery and Immune Activation. J Pharm Sci. 2017 Oct;106(10):3113-3119.
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