Product Name :
Tat-NR2B9c
CAS NO. :
500992-11-0
Formula :
C105H188N42O30
Molecular Weight::
2518.88
Target:
iGluR，NO Synthase
Serial Number:
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Leu-Ser-Ser-Ile-Glu-Ser-Asp-Val
Short serial number :
YGRKKRRQRRRKLSSIESDV
Purity:
95%
Description :
Tat-NR2B9c TFA is a membrane-permeable postsynaptic density-95 (PSD-95)-binding (decoy) peptide and a neuroprotective agent that can inhibit neuronal excitotoxicity.
References:
[1]. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. [2]. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009. [3]. Teves LM, et al. Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species. J Cereb Blood Flow Metab. 2016 Mar;36(3):555-61. [4]. Jing Fan, et al. N-methyl-D-aspartate Receptor Subunit- And Neuronal-Type Dependence of Excitotoxic Signaling Through Post-Synaptic Density 9. J Neurochem. 2010 Nov;115(4):1045-56.
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