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Product Name: LOXO-101
Chemical Name: (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
SMILES Code: O=C(N1CC[[email protected]@H](C1)O)NC2=C3N=C(N4CCC[[email protected]@H]4C5=CC(F)=CC=C5F)C=CN3N=C2
CAS NO: 328898-40-4 Product: AMG 837 (sodium salt)
Synonym: ARRY470; ARRY-470; ARRY 470; LOXO 101; LOXO101
Chemical Formula: C21H22F2N6O2Molecular Weight: 428.44
Appearance: Solid powderWeb Site:Medchemexpress
Purity: 98% (this data is for the first batch)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 8211; 4 C for short term (days to weeks) or -20 C for long term (months to years).Glucagon Receptor inhibitors
Solubility: Soluble in DMSO, not in water
Background Description: LOXO-101 (ARRY-470) is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibition of all three TRK family members in binding and cellular assays, with 100x selectivPubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/11133086

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Author: DNA_ Alkylatingdna